HDx Therapy

Expanded Hemodialysis may make a World of Difference

for Patients, Clinicians & Healthcare Systems

Expand renal possibilities for all HD patients

Expanded hemodialysis therapy is the next evolution in hemodialysis that brings us a step closer to the natural kidney.1HDx therapy enabled by Theranova dialyzer* features an innovative membrane for higher permeability compared to HD and HDF to enable efficient removal of large-middle molecules (25 kDa to <60 kDa).2,3,4
Some of these large uremic toxins have been linked to inflammation, cardiovascular disease and other co-morbidities in dialysis patients.5,6

HDx therapy delivers meaningful and relevant innovation for dialysis patients

Doctor and patient talking and smiling

Safety Evidence

When creating internal filtration through HDx therapy and MCO membrane, the permeability of the MCO Theranova membrane for endotoxins is not significantly different vs low-flux, high-flux, and high cut-off membranes.7

Doctor walking with female patient


HDx therapy targets the efficient removal of large-middle molecules, many of which have been linked to the development of inflammation, cardiovascular disease, and other co-morbidities in dialysis patients13,14 while maintaining stable serum albumin levels over the long term.3, 15

Three doctors talking in the hallway

Clinical Effectiveness

HDx therapy addresses pathophysiological responses and clinical outcomes that challenge patients undergoing hemodialysis for treatment of end stage kidney disease.8

Patient reported measures

Patient-Reported Measures

HDx therapy may improve patient-reported outcomes related to quality of life aspects of kidney disease, including symptom burden, restless legs syndrome criteria, pruritus and dialysis recovery time.4,8,9

Operational Efficiency

Operational Efficiency

With HDx therapy, not only can Theranova dialyzer provide advanced performance compared to HD and HDF along with clinical and patient-reported benefits but HDx therapy can be prescribed using regular HD workflow and infrastructure.6,10 

Provide Expanded Hemodialysis. Retain HD Simplicity.     

Doctors standing in a circle


While HDx therapy may offer the potential to improve access to care and to help improve the effectiveness and quality of care, HDx therapy may simultaneously offer dialysis service providers and healthcare systems alike the opportunity to reduce the total cost of care.11,12 

Baxter's Commitment to You

HDx therapy provides high-performance hemodialysis treatments by targeting the efficient removal of large-middle molecules (25 kDa to < 58 kDa), many of which have been linked to the development of inflammation, cardiovascular disease and other comorbidities in dialysis patients.1,3,4

The Healthcare Concern

Medium-middle and large-middle molecules effect a range of biological functions including inflammation and cardiovascular risk. The retention of these molecules has been associated with higher mortality in chronic kidney disease patients.6

The Challenge

Traditional high-flux membranes prescribed for use in hemodiafiltration (HDF) and high-flux hemodialysis (HF-HD) treatments have limited capability to remove medium-middle and large-middle molecule uremic toxins.1,5,6

Reference Library

Hear from patients, nephrologists, and nurses alike as they share their experience prescribing HDx therapy. Be reassured by the pioneering commitment of Baxter to dialysis patients the world over and learn how Theranova dialyzers are made.

HDx Therapy Evidence Compendium

On-going research and clinical reporting are an integral part of the HDx therapy journey. Explore the the expanding evidence related to HDx therapy enabled by Theranova dialyzer that nephrologists around the world continue to generate. 


HDx Therapy Brochure

Here you can find the HDx therapy brochure with more information about prescribing HDx therapy for your hemodialysis patients.


HDx Therapy Specification Sheets

Here you can find the detailed profiles of Theranova dialyzers.

Learn more about HDx

Baxter Announces

U.S. FDA De Novo Authorization for Theranova Dialyzers Enabling HDx Therapy

View resource
Stories • HDx
Patient testimonial from APAC
Stories • HDx

Important Safety Information

Theranova dialyzers are indicated for treatment of chronic and acute renal failure by hemodialysis.
*Do not use Theranova dialyzers in HDF or HF mode.

For safe and proper use of this device, please refer to Instructions for Use.

CE 0123