- Implementation of HDx, integrated with strategies blocking an excessive secretion of inflammatory mediators, may offer a new therapeutic approach to chronic inflammation and PEW in ESRD
- Urgent need for clinical trials of interventions designed to decrease levels of these middle molecules in CKD patients
- Inflammation is an important contributor to both the development and progression of kidney injury. Some of the risk factors potentiating inflammation in the early stages of CKD are readily preventable
- importance of internal filtration as a solute removal mechanism in high-flux HD is highlighted
- MCO membranes provide efficient removal of free light chains resulting in significantly decreased predialysis FLC concentrations in the plasma of ESRD patients after 4 week treatment